microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer
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microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer. / Crone, Stephanie Geisler; Jacobsen, Anders; Federspiel, Birgitte; Bardram, Linda; Krogh, Anders; Lund, Anders H.; Friis-Hansen, Lennart.
In: Molecular Cancer, Vol. 11, No. 71, 2012, p. 71.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - microRNA-146a inhibits G protein-coupled receptor-mediated activation of NF-κB by targeting CARD10 and COPS8 in gastric cancer
AU - Crone, Stephanie Geisler
AU - Jacobsen, Anders
AU - Federspiel, Birgitte
AU - Bardram, Linda
AU - Krogh, Anders
AU - Lund, Anders H.
AU - Friis-Hansen, Lennart
PY - 2012
Y1 - 2012
N2 - Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.
AB - Gastric cancer is the second most common cause of cancer-related death in the world. Inflammatory signals originating from gastric cancer cells are important for recruiting inflammatory cells and regulation of metastasis of gastric cancer. Several microRNAs (miRNA) have been shown to be involved in development and progression of gastric cancer. miRNA-146a (miR-146a) is a modulator of inflammatory signals, but little is known about its importance in gastric cancer. We therefore wanted to identify targets of miR-146a in gastric cancer and examine its biological roles.
KW - Animals
KW - CARD Signaling Adaptor Proteins
KW - Cell Line, Tumor
KW - Cytokines
KW - Disease Models, Animal
KW - Enzyme Activation
KW - Gene Expression Regulation, Neoplastic
KW - Humans
KW - Mice
KW - Mice, Knockout
KW - MicroRNAs
KW - Monocytes
KW - NF-kappa B
KW - Proteins
KW - Receptors, G-Protein-Coupled
KW - Signal Transduction
KW - Stomach Neoplasms
U2 - 10.1186/1476-4598-11-71
DO - 10.1186/1476-4598-11-71
M3 - Journal article
C2 - 22992343
VL - 11
SP - 71
JO - Molecular Cancer
JF - Molecular Cancer
SN - 1476-4598
IS - 71
ER -
ID: 40978042